A very nice article making an attempt to dispel the irrational fears of food additives. An imbalanced diet is much more of a danger than the additives in the food:
So, had I overdosed? Yes, but not on E numbers.

Dr Heaversedge wasn't worried about my E consumption, not even sodium nitrite (remember that 100-fold safety margin). What he was horrified by was the fact I'd eaten 418% of my recommended daily allowance of fat, 500% of my salt RDA and 218% of my sugar RDA. So the biggest nutritional culprits in my binge came in purely organic form and had no E numbers.
Don't miss the column that enumerates a few additives used by our ancestors in recent centuries. Strychnine and sulphuric acid in beer, anyone?