Very interesting article. Due to accidental loss of penis, parents and doctor attempted to raise son as daughter. Despite having been castrated and believing he was a girl, his behavior became increasingly masculine:
"The girl had many tomboy traits, such as abundant physical energy, a high level of activity, stubbornness, and being often the dominant one in a girl's group."

[...]

Yet by the time Brenda reached puberty at 13, she was feeling suicidal.

"I could see that Brenda wasn't happy as a girl," Janet recalled.

"She was very rebellious. She was very masculine, and I could not persuade her to do anything feminine. Brenda had almost no friends growing up. Everybody ridiculed her, called her cavewoman.